Pain & Opioid Metabolism Panel
Why painkillers work for some people but not others
CYP2D6 ultra-rapid metabolisers can experience opioid toxicity at standard doses; poor metabolisers receive no pain relief. This panel prevents dangerous over- or under-dosing.
Istanbul, Turkey
€260
Results in 10 days
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Postal saliva kit — no clinic visit required
Collect from home, post back in the pre-paid envelope. Results delivered digitally in 10 days.
What your saliva
sample reveals
CYP2D6 (codeine, tramadol, oxycodone metabolism)
OPRM1 (mu-opioid receptor — pain sensitivity)
COMT (pain perception & morphine requirement)
NSAIDs & COX-2 inhibitor metabolism (CYP2C9)
Anaesthesiologist-reviewed dosing guide
Best for: Anyone planning surgery, managing chronic pain, or who has had unexpected reactions to codeine or tramadol
Explore each panel
Browse every category covered in your Pain & Opioid Metabolism Panel — click a marker to see the action it unlocks.
The liver enzymes that determine whether standard drug doses are safe and effective for you.
CYP2D6 phenotype
CYP2D6 (chr22)
CYP2C19 phenotype
CYP2C19 (chr10)
CYP2C9 phenotype
CYP2C9 (chr10)
CYP3A4/5 activity
CYP3A4 (chr7)
Turn data into action
Every finding in your report comes with a concrete next step. Here's what your results can unlock.
Carry Your Drug-Compatibility Profile for Life
Carries for lifeTriggered by: Any CYP450 variant identified
200+
medications covered by your profile
Click to collapse
What this result reveals:
How your CYP2D6, CYP2C19, CYP2C9, and CYP3A4/5 phenotypes interact with over 200 specific medications — covering every major therapeutic area from psychiatry to cardiology to anaesthesia.
Download your printable drug-compatibility card from the portal — bring it to every GP, specialist, and hospital visit
Share the full report with your pharmacist to screen current medications for interactions
If hospitalised: insist your pharmacogenomics report is reviewed before any new prescription, especially pain medication
1 in 3 people carry a CYP450 variant that significantly affects drug metabolism. CYP2D6 PM status eliminates all analgesic effect from codeine — a medication given daily in hospitals worldwide.
End Psychiatric Medication Trial-and-Error
Most impactfulTriggered by: CYP2D6, CYP2C19, or SLC6A4 variants
4 weeks
average time to effective treatment (vs. 9 months)
Click to see the full action protocol →
Get Anticoagulant Dosing Right First Time
Safety criticalTriggered by: VKORC1 or CYP2C9 variants
−60%
time outside therapeutic range with genotype dosing
Click to see the full action protocol →
Every action protocol above is included in your digital report, reviewed by a specialist.
Who benefits most
Experienced unexpected side effects
A medication your GP described as standard caused an unusually strong or completely absent reaction. Your CYP450 enzyme profile explains exactly why.
Starting a new long-term prescription
About to begin antidepressants, statins, or blood thinners. Getting your pharmacogenomics first means getting the right drug and dose on the very first attempt.
Multiple medication changes with no result
Gone through 3 or more antidepressants or pain medications with poor results. That pattern has a genetic explanation in the majority of cases.
60 pages of actionable insight
Not a raw data dump — a structured clinical report written in plain language, reviewed by your specialist before delivery, with every finding mapped to a concrete action.
Pain & Opioid Metabolism Panel — Genetic Report
Sample results · For illustrative purposes
PM
CYP2D6 status
Poor metaboliser — critical
Partial resp.
Clopidogrel
Consider alternative
−35%
Warfarin dose
Sensitive genotype
47
Medications affected
By your profile
CYP2D6 phenotype
CYP450 Panel
CYP2C19 phenotype
CYP450 Panel
CYP2C9 phenotype
CYP450 Panel
CYP3A4/5 activity
CYP450 Panel
+ 6 more markers in your full report
Report delivered digitally in 10 days from sample receipt. Reviewed by a specialist before release.
Inside your report
60-page clinical document
Executive summary — 1-page clinician overview
Full gene-by-gene findings with reference ranges
Your variant vs. 100,000-person population norms
Ranked intervention priority list by impact
Supplement & lifestyle protocol tailored to your results
GP & specialist summary letter (formatted for referrals)
Document library access via patient portal 24/7
Report formats included
Digital PDF
Download instantly from your portal
Patient portal
Interactive results, always accessible
GP referral letter
Formatted for your local doctor
Specialist letter
Category-specific clinical summary
Included free with every test
Your patient portal is activated the moment your saliva kit is dispatched. Every result, action item, specialist message, and document — in one place, accessible 24/7 from any device.
Full report library
PDF + interactive results, always accessible
Secure specialist messaging
Direct line to your doctor, included free
Protocol reminders
Daily supplement and action item tracker
Access from any device
Web portal — no app download required
GDPR encrypted storage
Your data is private and deletable on request
Mobile-optimised
Full functionality on phone, tablet, desktop
Your action plan
2/5 done40% complete — tap any item to mark done
Download drug-compatibility card (wallet size)
GP letter generated — CYP2D6 PM alert
Cardiologist clopidogrel alternative letter
Hospital alert wristband request (optional)
Pharmacist review of current medications
Portal activated instantly on kit dispatch. No app required — web-based access only.
From order to results:
4 simple steps
Everything managed through your patient portal — no clinic visits, no waiting rooms.
Saliva kit sent
Delivered to your door
Lab analysis
ISO 15189 certified lab
Specialist review
Doctor reads your results
Patient portal
Manage everything online
Patient portal: Order your kit, track shipping, view results, message your specialist, and access your complete report — all from one secure dashboard, available on any device 24/7.
Real questions from real patients
These are actual questions asked by patients about their Medication Safety results — answered in full by our specialists.
Dr. Aylin Kaya
MD PhDMolecular Genetics & Epigenetics Lead
Available for consultations Mon–Fri 9am–5pm (CET)
Dr. Mehmet Yilmaz
MDClinical Genetics & Pharmacogenomics Specialist
Available for consultations Tue–Sat 8am–4pm (CET)
Have a question about your specific situation? Our specialists reply within 2 hours.
Your questions, answered
Start knowing, not guessing.
Get in touch and your coordinator will send you the complete test guide, exact pricing, and your saliva kit within 2 hours. Free, no obligation.
Complete test guide & sample report emailed immediately
Saliva kit dispatched the same working day
Secure patient portal access on day of kit dispatch
Free 15-min pre-test call to answer all your questions
Results in 10 days — reviewed by a specialist before delivery
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Pain & Opioid Metabolism Panel
€260 · 10 days · Medication Safety
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Start your consultation and a coordinator will guide you through the process — pricing, timeline, and everything you need to know.
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